Organoids

Genetic Breakthrough in Childhood Kidney Cancer

Scientists from the Princess Máxima Center, together with international partners, discovered that a form of kidney cancer in children contains many more genetic changes than previously thought.

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Partner Institute

Sharing AI expertise at the Royal Palace in Amsterdam

At the end of 2024, the Palace Symposium on ‘Biological Design Through Artificial Intelligence’ took place at the Royal Palace Amsterdam. Prof. Gerard van Westen, Professor of AI and Pharmaceutical Chemistry at Leiden University and the lead of Oncode Accelerator’s Artificial Intelligence Platform, was invited to discuss applications of AI in developing innovative medicines.

Listen to his lecture (in Dutch): 

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Artificial Intelligence

Leveraging AI to Understand Oncogenesis

A recent publication presents an overview of the current knowledge around noncoding genetic variations and their (potential) roles in tumorigenesis, alongside a comparison of cutting-edge AI models that have helped to advance this body of work.

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Cell and Gene Therapy

Optimizing CAR-T Cell Manufacturing and Production

CAR-T cell therapy has revolutionized cancer treatment, but production and manufacturing remain complex and cost-intensive. A recent publication details there is potential for cost-minimization and optimization.

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Artificial Intelligence

First-in-Patient Dosing of AI-Designed Small Molecule

The first patients have been dosed in a phase I clinical trial of an AI-designed investigational new drug for treatment of patients with locally advanced/metastatic solid tumors.

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Biologics

Structure-Guided Design of Antibody-Based Cancer Immunotherapies

Structure-guided design of new cancer therapeutics has great potential, especially as structural biology technologies advance and become more accessible to scientists. A recent publication presents a case study.

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Artificial Intelligence and Organoids

Integrating Machine Learning with Patient-Derived Organoids for Multi-Drug Screening

Scientists integrated machine learning with an automated tumor-on-a-chip model to test and optimize combination chemotherapies in patient-derived organoids.

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Artificial Intelligence

AI in healthcare

De Volkskrant writes about AI and the various possibilities it offers in healthcare. The article features an interview with Jeroen de Ridder, PI within our sister organization Oncode Institute, who sheds light on how he has developed an AI tool that helps determine a tumor type within 30 minutes.  

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Artificial Intelligence

Pharma and AI 

Tech company IBM is providing an AI model to support the research of the German pharmaceutical company Boehringer Ingelheim. Their aim is to save time, especially at the beginning of the drug discovery process. 

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Patient Data

NESTOR

This year, all academic hospitals and the Netherlands Cancer Institute (NKI) will join forces to create NESTOR: a large database that consolidates data from as many people as possible with a hereditary predisposition to cancer. The project receives €3.4 million from KWF.


KWF and Radboudumc

Patient Data

Molecular and clinical patient data

Palga and Health-RI are collaborating to set up a platform for multidisciplinary consultation, with molecular and clinical data of patients who are discussed in a molecular tumor board. This platform should add great value for both patient care and scientific research into cancer pathology and new treatments.

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Patient Data

Mapping tumor DNA 

The GENAYA project, launched in 2022, aims to fully map tumor DNA in 1,000 adolescents/young adults (AYAs) with cancer using whole genome sequencing. This will be able to provide more insight into the genetic characteristics of tumours in these patients, which may lead to more tailored treatment. Currently, 22 hospitals have signed an agreement for participation in GENAYA, and around 100 patients have been included.

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